メールのお問い合わせ・資料請求はこちらから2020.03.18
「Scientific Reports」に研究論文掲載
Scientific Reports (2020) に弊社研究員の執筆した下記の研究論文が掲載されました。
題名
「GPNMB is expressed in human epidermal keratinocytes but disappears in the vitiligo lesional skin」
要旨
GPNMB is involved in multiple cellular functions including cell adhesion, stress protection and stem cell maintenance. In skin, melanocyte-GPNMB is suggested to mediate pigmentation through melanosome formation, but details of keratinocyte-GPNMB have yet to be well understood. We confirmed the expression of GPNMB in normal human epidermal keratinocytes (NHEKs) by reducing the expression using siRNA. A higher calcium concentration of over 1.25 mM decreased the GPNMB expression. Histological staining showed that GPNMB was expressed in the basal layer of normal skins but completely absent in vitiligo skins. The normal expression of GPNMB in nevus depigmentosus skin suggested that lack of GPNMB is characteristic of vitiligo lesional skins. IFN-γ and IL-17A, two cytokines with possible causal roles in vitiligo development, inhibited GPNMB expression in vitro. These findings indicate a new target for vitiligo treatment, focusing on the novel role of IFN-γ and IL-17 in downregulating keratinocyte-GPNMB.
詳しくは、「Scientific Reports vol.10, 4930 (2020)」をご覧ください。
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一丸ファルコス株式会社 開発部
岐阜県本巣市浅木318番地１
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