メールのお問い合わせ・資料請求はこちらから2018.12.09
「AACR(American Association for cancer Research) Meetings」にてポスター発表
一丸ファルコス株式会社は、2018年12月9日（日）～12日（水）にカリフォルニア州サンディエゴにて開催された「AACR(American Association for cancer Research) Meetings 2018 / Targeting RAS-Driven Cancers」 において、下記のポスター発表を行いました。
題名
「Discovery of K-Ras(G12D)-targeting peptide KRpep-2d and its optimization strategy」（K-Ras（G12D）ターゲティングペプチドKRpep-2dの発見とその最適化戦略）
発表要旨
Mutated Ras proteins play important roles in cell differentiation, proliferation, and survival of various cancers. Especially, mutations at residue Gly12 where G12D in K-Ras is the most frequent mutation. Although over 30 years have passed since the discovery of mutated Ras in human cancers, effective drug targeting to Ras have not been marketed. Very recently, KRpep-2d, an artificial cyclic peptide was discovered as a first selective inhibitor to K-Ras(G12D) by phage display technology. KRpep-2d possesses low nanomol level activity in cell-free assays and shows preferable target-selectivity in cell-based assay. In this presentation, I review the biochemical activity, biophysical activity, and SAR of KRpep-2d. In addition, I will discuss a strategy to brush up KRpep-2d for its therapeutic use.
お問合せ先
一丸ファルコス株式会社 開発部
岐阜県本巣市浅木318番地１
ＴＥＬ：０５８－３２０－１０３０
ＦＡＸ：０５８－３２０－１０４１
担当：坂元、桝谷
資料請求・お問い合わせはこちらから
PREV
