メールのお問い合わせ・資料請求はこちらから2022.09.26
「第32回 IFSCC ロンドン大会」にて研究発表を行いました
一丸ファルコス株式会社は、2022年9月19日～22日の4日間、ロンドンにて開催された「第32回 IFSCC ロンドン大会」において、以下の研究内容をポスター発表しました。
発表テーマ
Effect of Artemisia capillaris fl ower extract on the microRNA-regulated HYBID expression in human dermal fibroblasts
（ヒト皮膚線維芽細胞におけるArtemisia capillaris flower抽出物のmicroRNA制御によるHYBID発現への影響）
要旨
Depolymerization of hyaluronic acid (HA) has been reported to be mediated by a novel protein called HYBID (HYaluronan-Binding protein Involved in hyaluronan Depolymerization) which binds and degrades high molecular size (>1000 kDa) HA into intermediate size fragments with molecular weights ranging from 10 kDa to 100 kDa. Although the multifaceted role of high molecular size HA is well-understood, the function of its intermediate size fragments in dermal fibroblasts is yet to be determined. Moreover, the regulation of HYBID expression by the presence of extrinsic aging factors such as UV or inflammation is well-documented both in vitro and in vivo, but its expression regulated by intrinsic aging factors is still absent. Therefore, this study aims to evaluate the function of intermediate size fragments of HA, to investigate the microRNA (miRNA)-based regulation of HYBID expression in newborn and adult fibroblasts, and to search for the effective material which can inhibit the expression of HYBID, thereby, can reduce not only intrinsic aging but also extrinsic aging of skin.
（注）IFSCC（国際化粧品技術者会連盟：The International Federation of Societies of Cosmetic Chemists） 1959年、8カ国の化粧品技術者会の参加により結成され、現在45の国と地域、約15,000名の会員を 擁する組織となっています。
【関連リンク】 32th IFSCC Congress
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